EGFR Mutations

EGFR mutations are commonly found in lung cancer and can impact treatment methods – but what exactly are EGFR mutations?

What happens when a cancer isn’t EGFR positive?

A cancer that’s EGFR negative wouldn’t be treatable with treatments that are designed to target EGFR cancers. 


Arora A., Scholar E.M. 2005. Role of Tyrosine Kinase Inhibitors in Cancer Therapy. Journal of Pharmacology and Experimental Therapeutics 315: 971-979.

WHO Cancer Fact Sheet

Epidermal Growth Factor Receptor Testing for Non-Small Cell Lung Cancer. Cancer.Net American Society of Clinical Oncology (ASCO). 2011.

Van Assche, K. et al. 2014. EGFR Mutation Positive Stage IV Non-Small-Cell Lung Cancer: Treatment Beyond Progression. Frontiers in Oncology 4: 350.

Bethune, G. et al. 2010. Epidermal growth factor receptor in lung cancer: an overview and an update. Journal of Thoracic Disease 2(1): 48-51